题目：A new ursane and a new oleanane triterpene acids from the whole plant of Spermacoce latifolia
作者：Ying Luo 1 , 2 ， Qiao-Lin Xu 3 ， Li-Mei Dong 1 , 2 ，Zhong-Yu Zhou 1 ，Yu-Chan Chen 4 ， Wei-Min Zhang 4 ， Jian-Wen Tan 1
单位：1.Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China ； 2.University of Chinese Academy of Sciences, Beijing 100049, China；3.Biotechnology Division, Guangdong Academy of Forestry, Guangzhou 510520, China； 4.Guangdong Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China
摘要： A phytochemical study on the whole plant of Spermacoce latifolia led to the isolation of a new ursane triterpene acid, 3β,6β,23-trihydroxy-urs-12,20(30)-dien-28-oic acid (1), and a new oleanane triterpene acid, 3β,6β,29-trihydroxy-olean-12-en-28-oic acid (2), together with seven known triterpenic acids (3–9). Their structures were established on the basis of detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI–MS and HR–ESI–MS techniques. All the compounds were isolated from S. latifolia for the first time. Compounds 3, 5, 6 and 9 were found to show in vitro growth inhibitory activity against three assayed human cancer cell lines MCF-7, NCI-H460 and HepG-2 with IC50 values from 9.53 to 80.20 mM. Compounds 1 and 3–9 were further revealed to show significantly in vitro α-glucosidase inhibitory activity with IC50 values from 0.009 to 0.422 mM, most of which were more potent than the reference compound acarbose (IC50 0.409 mM).
关键词：Spermacoce latifolia，Ursane，Oleanane，Triterpenoids，Cytotoxicity，α-Glucosidase inhibitor