Granularity and laxative effect of ultra-fine powder of Dendrobium officinale

2018-11-23 本站

题目:Granularity and laxative effect of ultra-fine powder of Dendrobium officinale


作者:DanDan Luo1, Chao Qu2,ZhenBiao Zhang1,JianHui Xie3,LieQiang Xu1,HongMei Yang1,CaiLan Li1, GuoSheng Lin1,HongFeng Wang4,5, ZiRen Su1,6

单位:1.School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China. 2.Guangdong Province Forestry Science and Technology Extension Station, Guangzhou, China.  3.Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.   4.Guangdong Provincial Key Laboratory of Bio-Control for the Forest Disease and Pest, Guangzhou, China.  5.Biotechnology Division, Guangdong Academy of Forestry, Guangzhou, China.6.Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, China.

摘要:Constipation is a common disorder that is a significant source of morbidity among people around the world ranging from 2% to 28%. Dendrobium officinale Kimura et Migo is a traditional herbal medicine and health food used for tonicity of the stomach and promotion of body fluid production in China. This study aimed to prepare the ultrafine powder of Dendrobium officinale (UDO) and investigate its laxative effect and potential mechanism in mice with diphenoxylate-induced constipation. Results indicated that the mean diameter (d50) of UDO obtained by ball milling was 6.56 μm. UDO (62.5, 125, and 250 mg/kg, p.o.) could significantly enhance the gastrointestinal transit ratio and promote fecal output. Moreover, UDO treatment resulted in significant increases in the serum levels of acetylcholinesterase (AChE), gastrin (Gas), motilin (MTL), and substance P (SP), and obviously decreased serum contents of somatostatin (SS). Taken together, UDO, which can be easily obtained through milling to a satisfactory particle size, exhibited obvious laxative effect in diphenoxylate-induced constipated mice, and the mechanism might be associated with elevated levels of AChE, Gas, MTL, SP, and reduced production of SS. UDO has the potential for further development into an alternative effective diet therapy for constipation.

关键词:constipation,Dendrobium officinale,diet therapy,diphenoxylate,laxative,ultrafine powder